What MAN1 does to the Smads. TGFbeta/BMP signaling and the nuclear envelope

The inner nuclear membrane protein MAN1 has been identified as an important factor in transforming growth factor beta/bone morphogenic protein (TGFbeta/BMP) signaling. Loss of MAN1 results in three autosomal dominant diseases in humans; all three characterized by increased bone density. Xenopus embr...

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Bibliographic Details
Published inThe FEBS journal Vol. 274; no. 6; pp. 1374 - 1382
Main Author Bengtsson, Luiza
Format Journal Article
LanguageEnglish
Published England 01.03.2007
Subjects
Animals
Bone Morphogenetic Proteins - metabolism
DNA-Binding Proteins
Humans
Membrane Proteins - metabolism
Nuclear Envelope - metabolism
Nuclear Proteins - metabolism
Phosphorylation
Signal Transduction
Smad Proteins - metabolism
Transforming Growth Factor beta - metabolism
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Summary:The inner nuclear membrane protein MAN1 has been identified as an important factor in transforming growth factor beta/bone morphogenic protein (TGFbeta/BMP) signaling. Loss of MAN1 results in three autosomal dominant diseases in humans; all three characterized by increased bone density. Xenopus embryos lacking MAN1 develop severe morphological defects. Both in humans and in Xenopus embryos the defects originate from deregulation of TGFbeta/BMP signaling. Several independent studies have shown that MAN1 is antagonizing TGFbeta/BMP signaling through binding to regulatory Smads. Here, recent progress in understanding MAN1 functions is summarized and a model for MAN1-dependent regulation of TGFbeta/BMP signaling is proposed.
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ISSN:1742-464X