Cytological and molecular changes in the atypical case of accelerated human aging

A complex research of cells of a patient with unusual form of premature ageing was made. The clinical picture is not typical for any of known forms of hereditary premature aging--progerias. Skin fibroblasts of the patient AG has limited proliferation capacity in vitro. It was shown by fluorescent-im...

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Bibliographic Details
Published inT͡S︡itologii͡a Vol. 44; no. 10; p. 930
Main Authors Kovina, M V, Khavinson, V Kh, Strekalov, D L, Solov'eva, D V, Vorobtsova, I E, Terekhov, S M, Pleskach, N M, Prokof'eva, V V, Spivak, I M, Timonina, G A, Mikhel'son, V M
Format Journal Article
LanguageRussian
Published Russia (Federation) 2002
Subjects
Adult
Aging - pathology
Anti-Inflammatory Agents - adverse effects
Cell Division
Cutis Laxa - diagnosis
Diagnosis, Differential
Fibroblasts - pathology
Hepatitis, Autoimmune - complications
Hepatitis, Autoimmune - drug therapy
Humans
In Situ Hybridization, Fluorescence
Liver Cirrhosis - prevention & control
Male
Prednisolone - adverse effects
Progeria - diagnosis
Skin - pathology
Werner Syndrome - diagnosis
Werner Syndrome - genetics
Werner Syndrome - pathology
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Summary:A complex research of cells of a patient with unusual form of premature ageing was made. The clinical picture is not typical for any of known forms of hereditary premature aging--progerias. Skin fibroblasts of the patient AG has limited proliferation capacity in vitro. It was shown by fluorescent-immunochemical hybridization (FISH-method), that the level of stable chromosome aberrations in AG blood lymphocytes was characteristic of aged 55-65 years, though as he was only 26 years old. Some characteristic peculiarities, typical for progerias, were found in the reaction of skin fibroblasts of AG to growth factors addition. Some clinical and biochemical peculiarities are results rather, than reasons of the disease. The conclusion is that the premature ageing in this case is a manifestation of Werner's syndrome--one of hereditary forms of accelerated senescence.
ISSN:0041-3771