Antimycins A10 approximately A16, seven new antimycin antibiotics produced by Streptomyces spp. SPA-10191 and SPA-8893

Seven new antimycin antibiotics, named antimycins A10, A11, A12, A13, A14, A15 and A16, were isolated from the fermentation broth of strains of Streptomyces spp. SPA-10191 and SPA-8893, along with known antimycins A1, A2, A3 and A4. The structures of the new antimycins were determined by spectral an...

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Bibliographic Details
Published inJournal of antibiotics Vol. 58; no. 7; pp. 460 - 467
Main Authors Hosotani, Nobuo, Kumagai, Kazuo, Nakagawa, Hiroyuki, Shimatani, Takuro, Saji, Ikutaro
Format Journal Article
LanguageEnglish
Published Japan 01.07.2005
Subjects
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Antimycin A - analogs & derivatives
Candida - drug effects
Fermentation
Molecular Structure
Streptomyces - classification
Structure-Activity Relationship
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Summary:Seven new antimycin antibiotics, named antimycins A10, A11, A12, A13, A14, A15 and A16, were isolated from the fermentation broth of strains of Streptomyces spp. SPA-10191 and SPA-8893, along with known antimycins A1, A2, A3 and A4. The structures of the new antimycins were determined by spectral analyses, including 2D NMR techniques. These compounds exhibited antifungal activity against Candida utilis.
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ISSN:0021-8820