Multifocal tuberculosis: fatal outcome due to toxic drug reactions

We report a case of multifocal tuberculosis with the following features: - skin involvement with multiple gommes disseminated on the left upper limb, the left flank, the right hypocondrium, and the right leg; - nodal involvement including the left supraclavicular, left axillary, right laterotracheal...

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Bibliographic Details
Published inRevue de pneumologie clinique Vol. 58; no. 1; p. 39
Main Authors Elouazzani, H, Bouchentouf, R, Rguibi, M, Rhorfi, I, Ouarssani, A, Yassir, Z, Abid, A, Alaoui-Tahiri, K
Format Journal Article
LanguageFrench
Published France 01.02.2002
Subjects
Adult
Antitubercular Agents - administration & dosage
Antitubercular Agents - adverse effects
Chemical and Drug Induced Liver Injury - pathology
Drug Therapy, Combination
Fatal Outcome
Female
Hepatic Encephalopathy - chemically induced
Hepatic Encephalopathy - pathology
Humans
Liver - drug effects
Liver - pathology
Tuberculosis, Miliary - diagnosis
Tuberculosis, Miliary - drug therapy
Tuberculosis, Miliary - pathology
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Summary:We report a case of multifocal tuberculosis with the following features: - skin involvement with multiple gommes disseminated on the left upper limb, the left flank, the right hypocondrium, and the right leg; - nodal involvement including the left supraclavicular, left axillary, right laterotracheal, pre and subcarineal, ceoeliomesenteric, and liver hilus nodes; splenic involvement; right pleural involvement; - spondylodiscitis of T11-T12 and of the head of the right fibula; - peritoneal involvement leading to ascitis; - multi-organ involvement. This 43-year-old woman had not particular history: no diabetes, no renal failure, no long-term corticosteroid treatment, no immunosuppressor treatment, negative HIV-1 and HIV-2 serology. Treatment with anti-tuberculosis agents led to severe drug reactions causing death due to hepatic encephalitis.
ISSN:0761-8417