The structure of physalin T from Physalis alkekengi var. franchetti

A new steroidal constituent named physalin T (3) was isolated from the aqueous extract of Physalis alkekengi var. francheti. Based on 1H and 13C NMR spectral studies the structure was assigned as 2,3-dihydrophysalin D, i.e., 5alpha,6beta-dihydroxy-2,3,5,6-tetrahydrophysalin B, which is the first exa...

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Published inJournal of asian natural products research Vol. 3; no. 3; pp. 199 - 205
Main Authors Kawai, M, Yamamoto, T, Makino, B, Yamamura, H, Araki, S, Butsugan, Y, Saito, K
Format Journal Article
LanguageEnglish
Published England 2001
Subjects
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Chromatography, Thin Layer
HeLa Cells - drug effects
Humans
Japan
Nuclear Magnetic Resonance, Biomolecular
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Secosteroids
Solanaceae - chemistry
Spectrophotometry, Infrared
Steroids - chemistry
Steroids - isolation & purification
Structure-Activity Relationship
Japan
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Summary:A new steroidal constituent named physalin T (3) was isolated from the aqueous extract of Physalis alkekengi var. francheti. Based on 1H and 13C NMR spectral studies the structure was assigned as 2,3-dihydrophysalin D, i.e., 5alpha,6beta-dihydroxy-2,3,5,6-tetrahydrophysalin B, which is the first example of a natural physalin possessing a saturated ring A moiety. The structure was confirmed by the chemical transformation from the known physalin D (2) to physalin T.
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ISSN:1028-6020