Alterations of inotropic function of isolated heart and extent of injury of cardiomyocytes after cannabinoid receptor activation during ischemia and reperfusion

It was found that CB1- and CB2-receptor activation by intravenous administration of the selective CB-agonist HU-210 at a dose 0.1 mg/kg prompts an increase of myocardial resistance to the pathogenic action of ischemia and reperfusion in vitro. The revealed effects of HU-210 do not depend on the acti...

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Bibliographic Details
Published inRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova Vol. 89; no. 9; p. 1108
Main Authors Maslov, L N, Lasukova, O V, Krylatov, A V, Lishmanov, Iu B, Pertwee, R
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.2003
Subjects
Animals
Anti-Arrhythmia Agents - administration & dosage
Anti-Arrhythmia Agents - pharmacology
Cannabinoid Receptor Agonists
Cannabinoids - metabolism
Dronabinol - administration & dosage
Dronabinol - analogs & derivatives
Dronabinol - pharmacology
Heart - drug effects
Male
Myocardial Ischemia - complications
Myocardial Ischemia - metabolism
Myocardial Reperfusion Injury - complications
Myocardial Reperfusion Injury - metabolism
Myocardium - metabolism
Rats
Rats, Wistar
Receptors, Cannabinoid - metabolism
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Summary:It was found that CB1- and CB2-receptor activation by intravenous administration of the selective CB-agonist HU-210 at a dose 0.1 mg/kg prompts an increase of myocardial resistance to the pathogenic action of ischemia and reperfusion in vitro. The revealed effects of HU-210 do not depend on the activation of CB-receptors in the myocardium.
ISSN:0869-8139