Cytokine production-adenosine deaminase activity relationship in pulmonary tuberculosis

• Published in: Problemy tuberkuleza no. 3; p. 38
• Main Authors: Knoring, B E, Titarenko, O T, Sakharova, I Ia, Loginova, G P, D'iakova, M E, Perova, T L, Simbirtsev, A S, Pigareva, N V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2000
• Subjects: Adenosine Deaminase - blood; Adolescent; Adult; Aged; Biomarkers - blood; Humans; Interleukin-1 - biosynthesis; Interleukin-2 - biosynthesis; Lymphocyte Activation - immunology; Middle Aged; Severity of Illness Index; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Tuberculosis, Pulmonary - blood; Tuberculosis, Pulmonary - immunology; Tumor Necrosis Factor-alpha - biosynthesis
• ISSN: 0032-9533

The serum activity of the enzyme adenosine desaminase (ADA) was studied in patients with infiltrative tuberculosis in relation to IL-1 beta, TNF-alpha, IL-2 productions, the magnitude of a lymphocytic proliferative response to PPD and PGA. There was an association of high ADA levels with the severity of a tuberculous process, with the least IL-2 production together with drastically increased IL1 beta and significant disorders in the TNF-alpha system. Moderate ADA increases reflect the regularly enhanced activity of immunocompetent cells in response to an infectious agent. The findings indicate that a simple biochemical test may be used for rapid preliminary evaluation of the severity of disease and immune performance.