Progress in the study of CCN family

• Published in: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA Vol. 22; no. 2; p. 179
• Main Authors: Su, Bing-Yin, Cai, Wen-Qin
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2002
• Subjects: Animals; Cattle; CCN Intercellular Signaling Proteins; Cell Differentiation - physiology; Connective Tissue Growth Factor; Cysteine-Rich Protein 61; Forecasting; Humans; Immediate-Early Proteins - chemistry; Immediate-Early Proteins - physiology; Insulin-Like Growth Factor Binding Proteins; Intercellular Signaling Peptides and Proteins - chemistry; Intercellular Signaling Peptides and Proteins - physiology; Intracellular Signaling Peptides and Proteins; Mice; Neoplasm Proteins - chemistry; Neoplasm Proteins - physiology; Neovascularization, Physiologic - physiology; Nephroblastoma Overexpressed Protein; Oncogene Proteins; Proto-Oncogene Proteins; Rats; Repressor Proteins - chemistry; Repressor Proteins - physiology; Swine; Wound Healing - physiology
• ISSN: 1000-2588

The last 5-6 years have seen the emergence of a new gene family that currently comprises CTGF, Cyr61, nov, elm1, HICP and WISP-3. The translational products of most CCN family members are secreted proteins that contain 343 to 381 amino-acid residues to compose 4 distinct structural modules, each having 38 conserved cysteine residues. These proteins have a variety of properties to affect the cellular behaviors such as growth, differentiation, adhesion and locomotion. They may play important roles in pregnancy, development and differentiation, angiogenesis, wound repair, fibrotic disorders, inflammation and tumor genesis.