Treatment of severe digoxin intoxication with antidote

In the case of severe digoxin intoxication, an antidote digoxin immune Fab (Digibind) is available. Digibind binds and inactivates digoxin. Measuring se-digoxin after administering Digibind (by standard measuring methods) is misleading as Digibind interferes with digitalis immunoassay measurements....

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Bibliographic Details
Published inUgeskrift for læger Vol. 170; no. 42; p. 3339
Main Authors Houlberg, Eva, Blicher, Thalia M Estrup
Format Journal Article
LanguageDanish
Published Denmark 13.10.2008
Subjects
Aged
Anti-Arrhythmia Agents - blood
Anti-Arrhythmia Agents - poisoning
Aortic Aneurysm, Abdominal - surgery
Digoxin - administration & dosage
Digoxin - blood
Digoxin - poisoning
Drug Overdose
Humans
Immunoglobulin Fab Fragments - therapeutic use
Male
Postoperative Complications - etiology
Postoperative Complications - metabolism
Renal Insufficiency - etiology
Renal Insufficiency - metabolism
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Summary:In the case of severe digoxin intoxication, an antidote digoxin immune Fab (Digibind) is available. Digibind binds and inactivates digoxin. Measuring se-digoxin after administering Digibind (by standard measuring methods) is misleading as Digibind interferes with digitalis immunoassay measurements. The effect of Digibind must be estimated on the basis of the disappearance of the patient's symptoms and cardiac abnormalities. A case involving Fab therapy of a digoxin-overdosed patient is reported.
ISSN:1603-6824