Acute renal failure caused by VIP-secreting tumor

A 74-year-old woman had secretory diarrhea, severe metabolic acidosis, hypokalemia, hypovolemia, and acute renal failure caused by a pancreatic vasoactive intestinal polypeptide (VIP)-secreting tumor. Vipoma is a rare neuroendocrine tumor. Morbidity and mortality are related to long-standing dehydra...

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Bibliographic Details
Published inGiornale italiano di nefrologia Vol. 20; no. 4; p. 419
Main Authors Lambertini, D, Bottini, E, Talassi, E, Tarchini, R, Gaetti, L, Bellomi, A
Format Journal Article
LanguageItalian
Published Italy 01.07.2003
Subjects
Acute Kidney Injury - etiology
Aged
Female
Humans
Pancreatic Neoplasms - complications
Vipoma - complications
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Summary:A 74-year-old woman had secretory diarrhea, severe metabolic acidosis, hypokalemia, hypovolemia, and acute renal failure caused by a pancreatic vasoactive intestinal polypeptide (VIP)-secreting tumor. Vipoma is a rare neuroendocrine tumor. Morbidity and mortality are related to long-standing dehydration and electrolyte and acid-base disturbance resulting in acute renal failure. Diagnosis requires the documentation of large volumes of secretory diarrhea, elevated VIP plasma levels, and the localization of the VIP-secreting tumor. Metastases are present in 50% of patients at the time of diagnosis. Treatment includes correction of volume, electrolyte, and metabolic abnormalities; CVVH during ARF; pharmacotherapy to decrease gastrointestinal secretion; and surgical resection of the vipoma.
ISSN:0393-5590