Semax prevents elevation of nitric oxide generation caused by incomplete global ischemia in the rat brain

A twofold increase in the nitric oxide (NO) production and a moderate increase in the content of secondary products of lipid peroxidation was observed in Wistar rats with incomplete global ischemia model induced by the bilateral occlusion of common carotid arteries. A clear correlation was observed...

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Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 64; no. 2; p. 31
Main Authors Fadiukova, O E, Alekseev, A A, Bashkatova, V G, Tolordava, I A, Kuzenkov, V S, Mikoian, V D, Vanin, A F, Koshelev, V B, Raevskiĭ, K S
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.2001
Subjects
Adrenocorticotropic Hormone - analogs & derivatives
Adrenocorticotropic Hormone - pharmacology
Animals
Arterial Occlusive Diseases - complications
Brain - metabolism
Carotid Artery Diseases - complications
Carotid Artery, Common
Glycine - pharmacology
Ischemic Attack, Transient - etiology
Ischemic Attack, Transient - metabolism
Ligation
Lipid Peroxidation - drug effects
Male
Neuroprotective Agents - pharmacology
Nitric Oxide - biosynthesis
Peptide Fragments - pharmacology
Rats
Rats, Wistar
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Summary:A twofold increase in the nitric oxide (NO) production and a moderate increase in the content of secondary products of lipid peroxidation was observed in Wistar rats with incomplete global ischemia model induced by the bilateral occlusion of common carotid arteries. A clear correlation was observed between the NO content in the rat brain and the level of neurological disturbance manifestations in the ischemized animals. The synthetic peptide semax (a fragment of ACTH4-7 Pro-Gly-Pro) in a dose of 0.3 mg/kg prevented from the development of both neurological disturbances and excess NO production in the rat brain cortex.
ISSN:0869-2092