Goodpasture syndrome associated with p-ANCA microscopic vasculitis: a rare entity to recognize

Some autoimmune diseases may be found presenting simultaneously antibodies (Abs) against basal membrane and anti-neutrophil cytoplasm (ANCA). The clinical picture is that of the Goodpasture syndrome with anti-basement membrane Abs associated with an ANCA-associated small-vessel vasculitis (micro-PAN...

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Bibliographic Details
Published inRevue médicale suisse Vol. 5; no. 207; pp. 1330 - 1334
Main Authors Pralong, G, Fournier, C, Dayer, E, Meier, P
Format Journal Article
LanguageFrench
Published Switzerland 10.06.2009
Subjects
Anti-Glomerular Basement Membrane Disease - diagnosis
Anti-Glomerular Basement Membrane Disease - drug therapy
Anti-Glomerular Basement Membrane Disease - immunology
Antibodies, Antineutrophil Cytoplasmic - immunology
Autoantibodies - immunology
Biomarkers - metabolism
Diabetes Complications
Humans
Immunologic Factors - immunology
Immunosuppressive Agents - therapeutic use
Male
Middle Aged
Prognosis
Treatment Outcome
Vasculitis - diagnosis
Vasculitis - drug therapy
Vasculitis - immunology
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Summary:Some autoimmune diseases may be found presenting simultaneously antibodies (Abs) against basal membrane and anti-neutrophil cytoplasm (ANCA). The clinical picture is that of the Goodpasture syndrome with anti-basement membrane Abs associated with an ANCA-associated small-vessel vasculitis (micro-PAN). The arisen of these two pathological entities is nevertheless too frequent to be the fruit of the only fate. The pathophysiological hypothesis remains that of the micro-PAN initially creates lesions of the basement membrane facilitating the formation of Abs against some constituents of this latter. The prognosis remains controversial, leaving open this issue. This article aims to present a recent literature revue dealing with the simultaneous presence of these two auto-immune diseases.
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ISSN:1660-9379