Pyoderma gangrenosum: case series

Pyoderma Gangrenosum (PG) is a rare ulcerative cutaneous condition with distinctive characteristics, and the aetiology is not clear yet. PG is commonly associated with inflammatory bowel disease (Ulcerative Colitis and Crohn's disease). The features of PG are not specific histopathologically an...

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Published inClinica terapeutica Vol. 158; no. 4; p. 325
Main Authors Richetta, A G, Maiani, E, Carboni, V, Carlomagno, V, Cimillo, M, Mattozzi, C, Calvieri, S
Format Journal Article
LanguageItalian
Published Italy 01.07.2007
Subjects
Adrenal Cortex Hormones - therapeutic use
Adult
Dermatologic Agents - therapeutic use
Female
Humans
Immunoglobulins, Intravenous - therapeutic use
Immunosuppressive Agents - therapeutic use
Inflammatory Bowel Diseases - complications
Male
Middle Aged
Pyoderma Gangrenosum - complications
Pyoderma Gangrenosum - diagnosis
Pyoderma Gangrenosum - therapy
Tumor Necrosis Factor-alpha - antagonists & inhibitors
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Summary:Pyoderma Gangrenosum (PG) is a rare ulcerative cutaneous condition with distinctive characteristics, and the aetiology is not clear yet. PG is commonly associated with inflammatory bowel disease (Ulcerative Colitis and Crohn's disease). The features of PG are not specific histopathologically and for this reason diagnosis is based on clinical feature. There is no single successful treatment for PG. In fact certain type of lesions respond more readily to some therapies than others. Local treatments (advanced wound care, local corticosteroids, local immunomodulator agents) may be sufficient for some clinical features, while others may be required systemic therapy (corticosteroids, immunosuppressive therapy, intravenous immune globulins, TNF-alpha blocking agents). We present four cases of PG associated with inflammatory bowel diseases treated with different therapeutic approaches.
ISSN:0009-9074