In vitro activity of fluconazole against Candida albicans isolated from blood culture

The in vitro activity of fluconazole against 65 Candida albicans isolated from blood culture in 1995, 1996 and 1997 was studied by macrodilution and disk diffusion methods. The MIC ranged from 0.03 to 64 microg/ml, with 93.6% of strains being inhibited with 1 microg/ml fluconazole; the mode MIC was...

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Bibliographic Details
Published inRevista española de quimioterapia Vol. 11; no. 4; pp. 339 - 343
Main Authors Pemán, J, Cantón, E, Orero, A, Ubeda, P, Viudes, A, Pastor, A, Gobernado, M
Format Journal Article
LanguageSpanish
Published Spain 01.12.1998
Subjects
Antifungal Agents - pharmacology
Candida albicans - drug effects
Candidiasis - blood
Candidiasis - microbiology
Diffusion
Fluconazole - pharmacology
Humans
Indicator Dilution Techniques
Microbial Sensitivity Tests
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Summary:The in vitro activity of fluconazole against 65 Candida albicans isolated from blood culture in 1995, 1996 and 1997 was studied by macrodilution and disk diffusion methods. The MIC ranged from 0.03 to 64 microg/ml, with 93.6% of strains being inhibited with 1 microg/ml fluconazole; the mode MIC was 0.25 microg/ml. Using this method, only one strain was resistant and another was susceptible depending on the dose. By diffusion, eight strains were susceptible, 53 intermediate, and four resistant. The strains susceptible by dilution were also susceptible by diffusion, but the strains resistant by diffusion were not always resistant by dilution. We find it therefore useful to determine the MIC of fluconazole to the C. albicans resistant by diffusion.
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ISSN:0214-3429