Ganglionic blockers in abdominal surgery: facts and hypotheses. I. Benzohexonium and motor function of the gastrointestinal system in the early postoperative period

• Published in: Vestnik hirurgii im. I.I. Grekova Vol. 161; no. 4; p. 11
• Main Authors: Kurygin, Al A, Maĭstrenko, N A, Polushin, Iu S, Revin, G O
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2002
• Subjects: Animals; Dogs; Duodenum - drug effects; Ganglionic Blockers - administration & dosage; Ganglionic Blockers - pharmacology; Ganglionic Blockers - therapeutic use; Gastrointestinal Diseases - prevention & control; Gastrointestinal Motility - drug effects; Hexamethonium Compounds - administration & dosage; Hexamethonium Compounds - pharmacology; Hexamethonium Compounds - therapeutic use; Humans; Injections, Intramuscular; Intestine, Small - drug effects; Jejunum - drug effects; Myoelectric Complex, Migrating - drug effects; Postoperative Complications - prevention & control; Postoperative Period; Pylorus - surgery; Risk Factors; Stomach - surgery; Stomach Ulcer - surgery; Telemetry; Time Factors; Vagotomy, Truncal
• ISSN: 0042-4625

The method of registration of the intraluminal pressure was used to study the function of the stomach, small intestine and sigmoid colon under conditions of partial ganglionic blockade in the first days after truncal vagotomy and resection of the stomach. It was found that benzohexonium in doses 0.1-0.3 mg/kg failed to substantially decrease the frequency of early functional motor-evacuation disorders of the "operated" stomach, but the results of using N-cholinolytic was better after truncal vagotomy than after resection of the stomach. Benzohexonium in doses 0.1-0.2 mg/kg failed to considerably stimulate the motor function of the small intestine while the doses of 0.3-0.4 mg/kg resulted in a decrease of its contractile activity. No reliable changes in the qualitative and quantitative parameters of the sigmoid colon motor function were found against the background of ganglionic blockade. So, for prevention and correction of early postoperative motor-evacuation disorders of the gastrointestinal tract the ganglionic blockade with N-cholinolytics should not be taken as a method of choice or a variant of monotherapy.