Neonatal lupus erythematosus with recurrent pancytopenia: a case report

Neonatal lupus erythematosus is an immune-mediated disease associated with the transplacental passage of maternal autoantibodies, primarily anti-Ro (SS-A) and anti-La (SS-B). The major clinical manifestations are isolated congenital heart block and cutaneous lupus lesions. Other symptoms include hem...

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Published inJournal of microbiology, immunology and infection Vol. 35; no. 4; pp. 262 - 264
Main Authors Wang, Ling-Jen, Yang, Yao-Hsu, Lin, Ming-I, Chiang, Bor-Luen, Mu, Shu-Chi
Format Journal Article
LanguageEnglish
Published England 01.12.2002
Subjects
Antibodies, Antinuclear - analysis
Autoantibodies - blood
Female
Heart Block - complications
Heart Block - diagnosis
Humans
Infant
Infectious Disease Transmission, Vertical
Lupus Erythematosus, Cutaneous - complications
Lupus Erythematosus, Cutaneous - genetics
Lupus Erythematosus, Cutaneous - pathology
Male
Pancytopenia - complications
Pregnancy
Recurrence
Sjogren's Syndrome - genetics
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Summary:Neonatal lupus erythematosus is an immune-mediated disease associated with the transplacental passage of maternal autoantibodies, primarily anti-Ro (SS-A) and anti-La (SS-B). The major clinical manifestations are isolated congenital heart block and cutaneous lupus lesions. Other symptoms include hematologic and hepatic abnormalities. We report a male neonate, born to a mother with Sjögren's syndrome, who experienced cutaneous lupus lesions and 2 episodes of pancytopenia. Both anti-Ro and anti-La antibodies were positive in infant and mother.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ISSN:1684-1182