Neuroimmunopathological mechanisms of preclinical epileptogenesis and their correction by cycloferon

The peculiarities of immunologic processes and immunocorrecting potential of Cyclopheron were studied in 62 patients with preclinical epileptogenesis. Using clinical, EEG and biochemical examination, expression of epileptogenesis was estimated as regressed, compensated, increasing, decompensated. Pr...

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Published inZhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 103; no. 12; p. 34
Main Authors Gromov, S A, Khorshev, S K, Bessmel'tsev, S S, Korsakova, E A, Poliakov, Iu I
Format Journal Article
LanguageRussian
Published Russia (Federation) 2003
Subjects
Acridines - therapeutic use
Adjuvants, Immunologic - therapeutic use
Adolescent
Adult
Antigens, CD - blood
Cytokines - blood
Electroencephalography
Epilepsy - blood
Epilepsy - drug therapy
Epilepsy - immunology
Fractals
Humans
Immunoglobulin E - blood
Immunoglobulin G - blood
Immunoglobulin M - blood
Lymphocytes - blood
Lymphocytes - drug effects
Lymphocytes - metabolism
Neuroimmunomodulation
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Summary:The peculiarities of immunologic processes and immunocorrecting potential of Cyclopheron were studied in 62 patients with preclinical epileptogenesis. Using clinical, EEG and biochemical examination, expression of epileptogenesis was estimated as regressed, compensated, increasing, decompensated. Preclinical stage of epilepsy was accompanied by disturbance of immunological brain reactivity the expression of which was correlated with a level of compensative epileptogenesis manifestation. The decrease of the latter is followed by intensive disintegration of neuroimmune interactions characterized by immunodeficiency of mixed type with significant presentation of neuroimmune disturbances. Therefore, a use of Cyclopheron, as a medication with multilevel immuno-correcting action, is expedient at initial stage of epilepsy.
ISSN:1997-7298