Modification of antitumor effect of vincristine by natural avermectins

The effect of avermectins (aversectin C, aversectin C1 and avermectin B1) on the vincristine antitumor action with respect to murine transplantable tumors was studied. It was shown that both the natural avermectins mixtures and the individual avermectin B1 potentiated the antitumor action of vincris...

Full description

Saved in:
Bibliographic Details
Published inAntibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] Vol. 49; no. 6; p. 3
Main Authors Driniaev, V A, Mosin, V A, Krugliak, E B, Sterlina, T C, Novik, T C, Ermakova, N V, Kublik, L N, Levitman, M Kh, Shaposhnikova, V V, Korystov, Iu N
Format Journal Article
LanguageRussian
Published Russia (Federation) 2004
Subjects
Animals
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antiparasitic Agents - administration & dosage
Dose-Response Relationship, Drug
Ivermectin - administration & dosage
Ivermectin - analogs & derivatives
Mice
Mice, Inbred DBA
Neoplasm Transplantation
Neoplasms, Experimental - drug therapy
Vincristine - administration & dosage
Online AccessGet more information

Cover

More Information
Summary:The effect of avermectins (aversectin C, aversectin C1 and avermectin B1) on the vincristine antitumor action with respect to murine transplantable tumors was studied. It was shown that both the natural avermectins mixtures and the individual avermectin B1 potentiated the antitumor action of vincristine on Ehrlich carcinoma, melanoma B16 and P388 lymphoid leukemia, including the vincristine resistant strain P388. Such an effect of the avermectins was observed only when they were administered after vincristine.
ISSN:0235-2990