Echinomycin production by Actinomadura sp. INA 654

An actinomycete strain designated as Actinomadura sp. INA 654 was isolated from a chernozem soil sample in the Voronezh Region by the soil sample treatment with millimetric waves (EHF band). The strain produced an antibiotic complex of 2 components, named A-654-I and A-654-II. Investigation of their...

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Bibliographic Details
Published inAntibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] Vol. 51; no. 9-10; p. 3
Main Authors Galatenko, O A, Terekhova, L P, Li, Iu V, Malkina, N D, Boĭkova, Iu V, Zenkova, V A, Katrukha, G S
Format Journal Article
LanguageRussian
Published Russia (Federation) 2006
Subjects
Actinobacteria - isolation & purification
Actinobacteria - metabolism
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
Bacteria - drug effects
Echinomycin - biosynthesis
Echinomycin - chemistry
Echinomycin - pharmacology
Microbial Sensitivity Tests
Russia
Soil Microbiology
Russia
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Summary:An actinomycete strain designated as Actinomadura sp. INA 654 was isolated from a chernozem soil sample in the Voronezh Region by the soil sample treatment with millimetric waves (EHF band). The strain produced an antibiotic complex of 2 components, named A-654-I and A-654-II. Investigation of their physico-chemical properties showed that A-654-I was identical to echinomycin, a heteropeptide lactone of the quinoxaline group with antitumor activity, while A-654-II proved to be likely a new natural compound. Production of echinomycin by a representative of the Actinomadura genus was detected for the first time. Up to now, only representatives of the Streptomyces genus were known to produce echinomycin.
ISSN:0235-2990