Use of polymerase chain reaction in the diagnosis of tuberculosis in children with diseases of the bronchopulmonary system

A comprehensive study was conducted to determine the activity of tuberculous infection in 115 patients who formed 3 groups: 1) patients with primary forms of tuberculosis; 2) those who were infected with Mycobacterium tuberculosis (MBT); and 3) those who were infected with bronchopulmonary diseases....

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Bibliographic Details
Published inProblemy tuberkuleza i bolezneĭ legkikh no. 6; p. 49
Main Authors Klochkova, L V, Korol', O I, Putintseva, I A, Skobeleva, N A, Vostriukhina, O A
Format Journal Article
LanguageRussian
Published Russia (Federation) 2004
Subjects
Adolescent
Bronchi - physiopathology
Child
Diagnosis, Differential
Humans
Lung - physiopathology
Polymerase Chain Reaction - methods
Tuberculosis, Pulmonary - diagnosis
Tuberculosis, Pulmonary - physiopathology
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Summary:A comprehensive study was conducted to determine the activity of tuberculous infection in 115 patients who formed 3 groups: 1) patients with primary forms of tuberculosis; 2) those who were infected with Mycobacterium tuberculosis (MBT); and 3) those who were infected with bronchopulmonary diseases. The detection of MBT DNA in the blood by polymerase chain reaction (PCR) using a highly sensitive four-primed diagnostic kit established that 80 patients with tuberculosis had positive results and their decrease as the patient had a course of tuberculostatic therapy. The fact that a third of patients from Groups 2 and 3 had highly positive results of PCR required that a preventive course of double therapy be used for 3 to 6 months.
ISSN:1728-2993