The pathogenetic significance of disruption of antioxidant homeostasis status in patients with hypertension

Antioxidative homeostasis was investigated in blood plasma and lymphocytes of patients with hypertonic disease (stage II). The intensification of lipid peroxidation was accompanied by accumulation of polyenic fatty acid derivatives and toxic dialdehydes and also by mobilization of lipid soluble vita...

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Published inVoprosy meditsinskoi khimii Vol. 46; no. 6; p. 591
Main Authors Paranich, A V, Lad, S N, Frolova, N A, Snegursiaia, I A, Koval', S N
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.2000
Subjects
Antioxidants - metabolism
Homeostasis
Humans
Hypertension - blood
Lipid Peroxidation
Lymphocytes - metabolism
Vitamin E - metabolism
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Summary:Antioxidative homeostasis was investigated in blood plasma and lymphocytes of patients with hypertonic disease (stage II). The intensification of lipid peroxidation was accompanied by accumulation of polyenic fatty acid derivatives and toxic dialdehydes and also by mobilization of lipid soluble vitamins. Vitamin E is probably involved into direct binding of toxic LPO products. Such changes provide high antioxidant activity and normal functioning of lymphocytes.
ISSN:0042-8809