Immune and enzyme disorders in patients with acute pancreatitis

Analysis of immune and enzyme disorders in 85 patients with acute pancreatitis shows that persistent imbalance of immunoregulatory T-lymphocytes with suppression predominance; reduction of all immunoglobulines number, imbalance in phagocytic immunity with height of absorbing activity of neutropils a...

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Bibliographic Details
Published inHirurgija (Moskva) no. 7; p. 21
Main Authors Briskin, B S, Iarovaia, G A, Savchenko, Z I, Rybakov, G S, Khalidov, O Kh, Mkhitarova, L A, Suplotova, A A
Format Journal Article
LanguageRussian
Published Russia (Federation) 2001
Subjects
Acute Disease
Adjuvants, Immunologic - therapeutic use
Adult
Aged
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Clinical Enzyme Tests
Humans
Immunoglobulins - immunology
Leukocytes - enzymology
Middle Aged
Neutrophils - immunology
Pancreatitis - diagnosis
Pancreatitis - enzymology
Pancreatitis - immunology
Pancreatitis - therapy
Phagocytes - immunology
Prognosis
Risk Factors
T-Lymphocytes - immunology
Thymus Hormones - administration & dosage
Thymus Hormones - therapeutic use
Time Factors
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Summary:Analysis of immune and enzyme disorders in 85 patients with acute pancreatitis shows that persistent imbalance of immunoregulatory T-lymphocytes with suppression predominance; reduction of all immunoglobulines number, imbalance in phagocytic immunity with height of absorbing activity of neutropils and stimultaneous decrease of their digestive capacity are prognostically unfavourable for high risk of pyonecrotic complications and lethal outcome. It is necessary to include immunocorrectors in combined therapy. Direct assessment of leukocytic elastase activity and alpha-IP level in blood plasma permits to evaluate spreading of inflammatory process and it severity, efficacy and prognosis of treatment.
ISSN:0023-1207