Molecular background of hyperandrogenism of ovarian origin

Ovarian androgens constitute substrates for estrogen formation, the key enzyme in androgen production being 17 alpha-hydroxylase/17,20 lyase, while in estrogen synthesis, aromatase. Both enzymes are constituents of a complex, comprising two proteins: cytochrome P450 reductase and respective cytochro...

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Bibliographic Details
Published inGinekologia polska Vol. 70; no. 5; p. 315
Main Authors Katulski, K, Warenik-Szymankiewicz, A, Trzeciak, W H
Format Journal Article
LanguagePolish
Published Poland 01.05.1999
Subjects
Androgens - blood
Cyclic AMP - blood
Estradiol - blood
Female
Follicle Stimulating Hormone - blood
Gene Expression - genetics
Gonadotropin-Releasing Hormone - blood
Humans
Hyperandrogenism - blood
Hyperandrogenism - diagnosis
Hyperandrogenism - genetics
Luteinizing Hormone - blood
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - diagnosis
Polycystic Ovary Syndrome - genetics
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Summary:Ovarian androgens constitute substrates for estrogen formation, the key enzyme in androgen production being 17 alpha-hydroxylase/17,20 lyase, while in estrogen synthesis, aromatase. Both enzymes are constituents of a complex, comprising two proteins: cytochrome P450 reductase and respective cytochromes P450c17 or P450arom, whose expression play an important role in a proper function of the ovaries and its genetically determined abnormalities may lead to appearance of clinical symptoms. Although it is difficult to clearly define the genetic background of disturbances, leading to hyperandrogenism, metabolic abnormalities, resulting in excessive androgen production, were observed in polycystic ovarian syndrome, hyperthecosis and hyperinsulinemia. In this review data from literature were presented and discussed regarding endocrine and molecular background of hyperandrogenism of ovarian origin.
ISSN:0017-0011