Influence of tumour size and uptake of 99mTc-octreotide on radio-guided surgery for neuroendocrine tumors

The aim of this study was to analyze the influence of scintigraphic uptake grade and tumour size on radio-guided surgery of neuroendocrine tumours (NETs) using 99mTc-EDDA/HYNIC-TOC (99mTc-octreotide). We investigated 21 patients with NET (F=8, M=13) for localization of 27 known lesions using a gamma...

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Bibliographic Details
Published inMinerva endocrinologica Vol. 34; no. 2; p. 89
Main Authors Hodolic, M, Fettich, J, Rubello, D
Format Journal Article
LanguageEnglish
Published Italy 01.06.2009
Subjects
Adult
Aged
Female
Follow-Up Studies
Humans
Image Enhancement
Male
Medical Records
Middle Aged
Neoplasm Staging
Neuroendocrine Tumors - diagnostic imaging
Neuroendocrine Tumors - pathology
Neuroendocrine Tumors - surgery
Octreotide - analogs & derivatives
Organotechnetium Compounds
Radionuclide Imaging
Radiopharmaceuticals
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Surgery, Computer-Assisted
Treatment Outcome
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Summary:The aim of this study was to analyze the influence of scintigraphic uptake grade and tumour size on radio-guided surgery of neuroendocrine tumours (NETs) using 99mTc-EDDA/HYNIC-TOC (99mTc-octreotide). We investigated 21 patients with NET (F=8, M=13) for localization of 27 known lesions using a gamma probe. Three to 6 hours before surgery, 550-650 MBq of 99mTc-octreotide was injected followed by immediate imaging prior to surgery. The uptake was graded on a scale from 0-4. Localization was confirmed by endoscopic ultrasound (EUS), computed tomography (CT) and/or magnetic resonance imaging (MRI). Morphological images were used to determine size of the lesion. Local measurements of radioactivity were performed during surgery using a gamma probe. Twenty lesions were successfully localized intraoperatively using a gamma probe (7=grade 4, 9=grade 3, 2=grade 2 and 2=grade 0). The size of successfully localized lesions ranged between 9 and 50 mm. Seven lesions were not localized successfully of which 6 were seen on scintigraphy (2=grade 4, 1=grade 3 and 3=grade 2). The 7th lesion was not seen on preoperative scintigraphy and not localized successfully. The size of unsuccessfully localized lesions ranged between 7 and 30 mm. High octreotide uptake (grade 3 and 4) influence radioguided surgery. Tumour size did not influence the success of localization of lesions by gamma probe.
ISSN:0391-1977