Expression of lymphocyte activation markers in patients with gastrointestinal tumors at different stages

Patients with gastrointestinal tumors revealed relatively high levels of activated lymphocytes. CD25 expression at later stages was much higher than at earlier ones (I-II). A relationship between CD25, CD71 and CD95 expression was established for metastatic spread of gastrointestinal tumors as well...

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Bibliographic Details
Published inVoprosy onkologij Vol. 51; no. 5; p. 571
Main Authors Oleĭnik, E K, Shibaev, M I, Oleĭnik, V M
Format Journal Article
LanguageRussian
Published Russia (Federation) 2005
Subjects
Adult
Aged
Antigens, CD - blood
Biomarkers, Tumor - blood
Colorectal Neoplasms - blood
Colorectal Neoplasms - pathology
fas Receptor - blood
Female
Fusion Regulatory Protein-1 - blood
Gastrointestinal Neoplasms - blood
Gastrointestinal Neoplasms - pathology
HLA-DR Antigens - blood
Humans
Lymphocyte Activation
Male
Middle Aged
Neoplasm Staging
Predictive Value of Tests
Receptors, Interleukin-2 - blood
Receptors, Transferrin - blood
Stomach Neoplasms - blood
Stomach Neoplasms - pathology
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Summary:Patients with gastrointestinal tumors revealed relatively high levels of activated lymphocytes. CD25 expression at later stages was much higher than at earlier ones (I-II). A relationship between CD25, CD71 and CD95 expression was established for metastatic spread of gastrointestinal tumors as well as a correlation between CD71 and CD98 expression for favorable course. A distinct activation phenotype can be identified for peripheral blood lymphocytes in burgeoning tumor which should be taken into account in prognosis.
ISSN:0507-3758