Protective effects of paraventricular nucleus stimulation and vasopressin on gastric ischemia-reperfusion injury in rats

• Published in: Sheng li hsüeh pao Vol. 54; no. 2; p. 133
• Main Authors: Zhang, Jian-Fu, Zhang, Yong-Mei, Yan, Chang-Dong, Zhou, Xiu-Ping, Qi, You-Jian
• Format: Journal Article
• Language: Chinese
• Published: China 25.04.2002
• Subjects: Afferent Pathways - physiology; Animals; Electric Stimulation; Male; Paraventricular Hypothalamic Nucleus - drug effects; Paraventricular Hypothalamic Nucleus - physiology; Rats; Rats, Sprague-Dawley; Reperfusion Injury - physiopathology; Reperfusion Injury - therapy; Stimulation, Chemical; Stomach - blood supply; Sympathetic Nervous System - physiology; Vagus Nerve - physiology; Vasopressins - pharmacology
• ISSN: 0371-0874

The effects of paraventricular nucleus (PVN) stimulation and vasopressin on gastric ischemia-reperfusion injury (GI-RI) were investigated in male SD rats of which the celiac artery was clamped for 30 min and reperfused for 1 h by removal of the clamp. The results were as follows. Both electrical and chemical stimulation of the PVN obviously attenuated the GI-RI. Bilateral electrolytic lesion of the nucleus tractus solitarius (NTS) or microinjection of AVP-V(1) receptor antagonist into the NTS could eliminate the protective effect of electrical stimulation of the PVN on GI-RI. Hypophysectomy did not influence the effect of electrical stimulation of the PVN. Both vagotomy and sympathectomy could increase the effect of stimulating PVN on GI-RI. Microinjection of arginine-vasopressin (AVP) into the PVN also attenuated the effect on GI-RI. These results suggest that the PVN and AVP participate in the regulation of GI-RI and play an important role in protection against GI-RI. This protective effect of PVN on GI-RI