Comparison CCR5de132 mutation in the CCR5 gene frequencies in Russians, Tuvinians, and in different groups of HIV-infected individuals

• Published in: Genetika Vol. 41; no. 11; p. 1559
• Main Authors: Apriatin, S A, Rakhmanaliev, E R, Nikolaeva, I A, Ruban, S V, Vazykhova, F G, Klimov, E A, Sulimova, G E, Sidorovich, I G
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.11.2005
• Subjects: Alleles; Asian Continental Ancestry Group; European Continental Ancestry Group; Female; Gene Frequency; HIV Seropositivity - genetics; HIV-1; Humans; Male; Receptors, CCR5 - genetics; Russia; Sequence Deletion; Russia
• ISSN: 0016-6758

The 32-bp deletion (CCR5del32 mutation) in the CCR5 (chemokine (C-C motif) receptor 5) gene, encoding CCR5 chemokine receptor, is one of the factors determining natural resistance to human immunodeficiency virus (HIV-1) infection. In the present study, the samples of Russians (n = 107), Tuvinians (n = 50), and HIV-infected individuals were examined for the presence of CCR5del32 mutation in the CCR5 gene. The CCR5del32 allele frequency in Russians and Tuvinians constituted 7.84 and 2%, respectively. Among HIV-1 infected individuals, two groups, of macrophage-tropic HIV-1 strain- and T-cell-tropic HIV-1 strain-infected were distinguished. The CCR5del32 allele frequency in the first group (6.45%) was lower than in the second one (8.73%). Statistical treatment of the HIV-1 infected individuals typing data showed that the difference in the CCR5del32 allele frequencies between the groups of sexually (macrophage-tropic) and parenterally (T-cell-tropic) infected individuals observed was within the limit of random deviation.