Role of biological defects in formation and development of bronchial asthma and potentialities of premorbid diagnosis

The paper considers bronchial asthma as a polygenic disease. It presents some data available in the literature on the role of genetic disorders in the development of atopic states and the authors' own findings of various biological defects detected in apparently healthy blood relatives of patie...

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Bibliographic Details
Published inVestnik Rossiĭskoĭ akademii medits︠i︡nskih nauk no. 12; p. 42
Main Authors Fedoseev, G B, Emel'ianov, A V, Lototskiĭ, A Iu, Marchenko, V N, Mineev, V N, Nemtsov, V I, Petrova, M A, Sinitsina, T M, Totolian, A A, Trofimov, V I, Shaporova, N L
Format Journal Article
LanguageRussian
Published Russia (Federation) 2000
Subjects
Asthma - diagnosis
Asthma - genetics
Disease Progression
Environmental Exposure - adverse effects
Genetic Predisposition to Disease
Humans
Hypersensitivity, Immediate - diagnosis
Hypersensitivity, Immediate - genetics
Prognosis
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Summary:The paper considers bronchial asthma as a polygenic disease. It presents some data available in the literature on the role of genetic disorders in the development of atopic states and the authors' own findings of various biological defects detected in apparently healthy blood relatives of patients with bronchial asthma. It is concluded that premorbid diagnosis is of importance in high risk persons.
ISSN:0869-6047