Production of immune mediators, induced by Lassa virus, in a human mononuclear cell culture

Infection of human mononuclear cells with Lassa virus leads to production of inflammatory cytokines (tumor necrosis factor and interleukin-1). These cytokines cause expression of adhesion receptors ICAM-1 and VCAM-1 by human endothelial cells. Mitogen-induced cell proliferation was not suppressed 1...

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Bibliographic Details
Published inVoprosy virusologiĭ Vol. 45; no. 6; p. 30
Main Authors Ignat'ev, G M, Strel'tsova, M A, Otrashevskaia, E V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.2000
Subjects
Cell Division - immunology
Cells, Cultured
Humans
Intercellular Adhesion Molecule-1 - metabolism
Interleukin-1 - immunology
Lassa virus - immunology
Monocytes - immunology
Monocytes - metabolism
Monocytes - virology
Tumor Necrosis Factor-alpha - biosynthesis
Vascular Cell Adhesion Molecule-1 - metabolism
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Summary:Infection of human mononuclear cells with Lassa virus leads to production of inflammatory cytokines (tumor necrosis factor and interleukin-1). These cytokines cause expression of adhesion receptors ICAM-1 and VCAM-1 by human endothelial cells. Mitogen-induced cell proliferation was not suppressed 1 h after infection of human mononuclear cells with Lassa virus in a dose of 0.01 PFU/cell. The capacity of cells to proliferation in response to mitogen stimulation decreased significantly only 4 h after infection.
ISSN:0507-4088