Use of phisiotens for the treatment of arterial hypertension in elderly patients

• Published in: Terapevtic̆eskii arhiv Vol. 73; no. 9; p. 17
• Main Authors: Ostroumova, O D, Mamaev, V I, Bagramova, Iu A, Rybkina, T E, Kuz'michev, I A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2001
• Subjects: Aged; Antihypertensive Agents - therapeutic use; Blood Pressure; Female; Heart Rate; Humans; Hypertension - drug therapy; Hypertension - physiopathology; Hypertension - psychology; Imidazoles - therapeutic use; Male; Memory; Middle Aged; Quality of Life; Thinking
• ISSN: 0040-3660

To study effectiveness and safety of physiotens in elderly patients with essential hypertension (degree 1-2). The trial enrolled 10 patients (6 males and 4 females) at the age of 60 to 75 years (mean age 66.4 +/- 3.7 years) with untreated or ineffectively treated essential hypertension (degree I-II by WHO classification). The disease stood for 17 +/- 5.3 years. Physiotens was given for 2 weeks in a single daily dose 0.2-0.4 mg. 24-h blood pressure monitoring, standard neuropsychological examination, echoCG, assessment of quality of life (Visual Analog Scale, Disability Scale) were performed before and after the treatment. Physiotens significantly reduced systolic and insignificantly diastolic pressure in daytime and at night; improved memory and thinking; 24 weeks of the treatment led to a decrease in left ventricular myocardium mass (by 13%, on the average) and in the thickness of left ventricular walls (by 7% on the average) as well as in life quality. Long-term physiotens treatment of elderly patients with mild and moderate hypertension provides a fall in day and night arterial pressure, regression of left ventricular myocardium mass, improves quality of life, memory and thinking.