Influence of staphylococcin T on Enterococcus sp. growth

Bacteriocins are ribosomally synthesised, extracellular bacterial products. Generally, spectrum of inhibition is limited to the same or closely related species to bacteriocin producer. Staphylococcin T is produced by Staphylococcus cohnii strain. The present study concerns influence of StT to 267 En...

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Published inMedycyna doświadczalna i mikrobiologia Vol. 59; no. 4; p. 309
Main Authors Białucha, Agata, Kozuszko, Sylwia, Gospodarek, Eugenia, Bugalski, Roman Marian, Gierlotka, Krzysztof
Format Journal Article
LanguagePolish
Published Poland 2007
Subjects
Anti-Bacterial Agents - pharmacology
Bacteriocins - chemistry
Bacteriocins - pharmacology
Drug Resistance, Multiple, Bacterial - drug effects
Enterococcus - drug effects
Enterococcus - growth & development
Enterococcus - isolation & purification
Enterococcus faecium - drug effects
Enterococcus faecium - growth & development
Enterococcus faecium - isolation & purification
Hospitals, University
Humans
Microbial Sensitivity Tests
Peptides - chemistry
Peptides - pharmacology
Peptides - secretion
Species Specificity
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Summary:Bacteriocins are ribosomally synthesised, extracellular bacterial products. Generally, spectrum of inhibition is limited to the same or closely related species to bacteriocin producer. Staphylococcin T is produced by Staphylococcus cohnii strain. The present study concerns influence of StT to 267 Enterococcus sp. strains growth isolated between 2003 and 2006 in Department of Microbiology University Hospital of dr. A. Jurasz in Bydgoszcz. S. cohnii T antagonistic ability evaluated towards bacteries on Mueller-Hinton Agar (bio Mérieux) in aerobic conditions. After 24 and 48 hours tested enterococci suspensions were plated perpendiculary. Susceptibility to antibiotics was assessed by disc diffusion method according to the guideless of Clinical and Laboratory Standards Institute and National Reference Centre for Antimicrobial Susceptibility. Among Enterococcus sp. strains tested 7.1% were sensitive to StT. The highest percentage of sensitive enterococci isolated from wound swabs, urine, blood and pus. Enterococcus faecium strains dominated (63.2%) among enterococci sensitive to StT. Moderate inhibition degree on S. cohnii T bacteriocin action was observed in majority sensitive enterococci strains. Enterococcus sp. sensitive to StT strains were frequently multidrug resistant (68.4%). According to the study results and increasing resistance to antibiotics, StT could be an alternative agent used to treat infections caused by Enterococcus sp.
ISSN:0025-8601