Effects of subchronic introduction of phenamine and haloperidol on development of spontaneous catalepsy in mice

The development of spontaneous and haloperidol-provoked catalepsy was investigated in more than 200 mice. It was found that spontaneous and haloperidolic catalepsies have the same mechanism of development. Injections of amphetamine followed by injections of haloperidol led to persistent changes of c...

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Bibliographic Details
Published inPatologicheskaia fiziologiia i eksperimental'naia terapiia no. 4; p. 22
Main Authors Kozlovskiĭ, V L, Prakh'e, I V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.10.2005
Subjects
Amphetamine - adverse effects
Animals
Apomorphine - adverse effects
Apomorphine - pharmacology
Brain - drug effects
Brain - physiology
Catalepsy - chemically induced
Catalepsy - etiology
Dopamine Agonists - adverse effects
Dopamine Agonists - pharmacology
Haloperidol - adverse effects
Injections
Mice
Time Factors
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Summary:The development of spontaneous and haloperidol-provoked catalepsy was investigated in more than 200 mice. It was found that spontaneous and haloperidolic catalepsies have the same mechanism of development. Injections of amphetamine followed by injections of haloperidol led to persistent changes of cateleptogenic behavior in mice. Less duration of spontaneous catalepsy may reflect functional condition of catecholaminergic brain systems similar to that of patients with psychotic disorder.
ISSN:0031-2991