Benign granular cell anal tumor

Granular cell tumors (GCT) are rarely located in the perianal area. Over the past 3 years, a 56 year-old man presented a papule of the right margin of the anus that had progressively increased in size (1.5 cm). Cell proliferation was located in the dermis and strongly expressed the S100 protein. It...

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Bibliographic Details
Published inLa Presse médicale (1983) Vol. 32; no. 5; p. 221
Main Authors Al Bouzidi, A, Choho, K, Cherradi, N, Rimani, M, Harket, A, Amarti Riffi, A, Labraimi, A, Achour, A, Saidi, A, Ben Omar, S
Format Journal Article
LanguageFrench
Published France 08.02.2003
Subjects
Anal Canal - pathology
Anus Neoplasms - diagnosis
Anus Neoplasms - pathology
Anus Neoplasms - surgery
Follow-Up Studies
Granular Cell Tumor - diagnosis
Granular Cell Tumor - pathology
Granular Cell Tumor - surgery
Humans
Immunohistochemistry
Male
Middle Aged
Time Factors
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Summary:Granular cell tumors (GCT) are rarely located in the perianal area. Over the past 3 years, a 56 year-old man presented a papule of the right margin of the anus that had progressively increased in size (1.5 cm). Cell proliferation was located in the dermis and strongly expressed the S100 protein. It was covered by a pseudo-epitheliomatous hyperplasia of the overlying epidermis. Forty months after local surgical excision, there was no sign of recurrence. Granular cell tumors are rare and usually benign. When cutaneous or mucosal, the pseudo-epitheliomatous hyperplasia of the overlying epithelium may, on superficial samples, be mistakenly diagnosed as squamous cell carcinomas. Malignant GCT may, histologically, appear identical to a benign GCT and only the appearance of metastases (generally after local recurrence) permits the subsequent diagnosis of malignancy.
ISSN:0755-4982