Effectiveness of artificial pneumothorax in the treatment of patients with pulmonary tuberculosis with multiple drug-resistant Mycobacteria

• Published in: Problemy tuberkuleza i bolezneĭ legkikh no. 8; p. 22
• Main Authors: Chukanov, V I, Mishin, V Iu, Sigaev, A T, Vasil'eva, I A, Osadchaia, O A, Perfil'ev, A V, Naumova, A N, Bagdasarian, T R
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2004
• Subjects: Adult; Antitubercular Agents - therapeutic use; Combined Modality Therapy; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pneumothorax, Artificial - methods; Tuberculosis, Multidrug-Resistant - drug therapy; Tuberculosis, Multidrug-Resistant - therapy; Tuberculosis, Pulmonary - drug therapy; Tuberculosis, Pulmonary - therapy
• ISSN: 1728-2993

The efficiency of treatment was compared in 2 groups of patients with destructive pulmonary tuberculosis and isolation of multidrug resistant Mycobacteria. In 43 patients of a study group, artificial pneumothorax (AP) was used during chemotherapy with reserve drugs while 43 patients of a control group received chemotherapy alone. AP was shown to be highly effective in treating patients with destructive pulmonary tuberculosis who isolated multidrug resistant Mycobacteria. Moreover, by the end of 12-month therapy, AP in combination with chemotherapy ensured cessation of bacterial isolation in 88.7% and cavernous closure in the lung in 86.8%, which was almost twice higher than that with therapy with reserve antituberculous drugs.