Effect of the stem cell factor on the morphology and functional state of mouse embryonic stem cells

The effect of the stem cell factor on the state of membranes and functional activity of mouse embryonic stem cells cultivated in LIF (Leukemia Inhibitory Factor) cytokine-free and LIF-containing media has been studied. It was shown that the stem cell factor induces changes in the viscosity of membra...

Full description

Saved in:
Bibliographic Details
Published inBiofizika Vol. 53; no. 4; p. 646
Main Authors Lobanok, E S, Belianovich, L M, Mezhevikina, L M, Volotovskiĭ, I D, Fesenko, E E
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2008
Subjects
Adenosine Triphosphate - biosynthesis
Animals
Cell Line
Cell Membrane - metabolism
Cell Proliferation - drug effects
Embryonic Stem Cells - cytology
Embryonic Stem Cells - metabolism
Leukemia Inhibitory Factor - pharmacology
Lipid Bilayers - metabolism
Membrane Fluidity - drug effects
Membrane Fluidity - physiology
Mice
Stem Cell Factor - pharmacology
Online AccessGet more information

Cover

More Information
Summary:The effect of the stem cell factor on the state of membranes and functional activity of mouse embryonic stem cells cultivated in LIF (Leukemia Inhibitory Factor) cytokine-free and LIF-containing media has been studied. It was shown that the stem cell factor induces changes in the viscosity of membrane lipid bilayer and increases the respiration rate, the ATP level, and the proliferation activity of embryonic stem cells. An intricate character of the LIF-dependent modification of biological effects of the stem cell factor was revealed.
ISSN:0006-3029