Liquid phase method of synthesizing polyamides binding DNA using oligocarboxamide blocks

A method was developed for the synthesis of sequence-specific polyamides on the basis of 4-amino-1-methylpyrrole-2-carboxylic acid, 4-amino-1-methylimidazole-2-carboxylic acid, beta-alanine, and gamma-aminobutyric acid. Dimeric and trimeric oligocarboxamides were used as building blocks. Our synthet...

Full description

Saved in:
Bibliographic Details
Published inBioorganicheskaia khimiia Vol. 30; no. 1; p. 110
Main Authors Sniiakov, A N, Feshchenko, M V, Riabinin, V A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.2004
Subjects
Amides - chemistry
DNA - chemistry
Nylons - chemistry
Online AccessGet more information

Cover

More Information
Summary:A method was developed for the synthesis of sequence-specific polyamides on the basis of 4-amino-1-methylpyrrole-2-carboxylic acid, 4-amino-1-methylimidazole-2-carboxylic acid, beta-alanine, and gamma-aminobutyric acid. Dimeric and trimeric oligocarboxamides were used as building blocks. Our synthetic scheme was applied for the synthesis of DNA minor groove binders containing up to twelve carboxamide units. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 1; see also http://www.maik.ru.
ISSN:0132-3423