Effects of short-term dietary administration of marginal levels of vitamin B(6)and fish oil on lipid composition and antioxidant defences in rat tissues

• Published in: Prostaglandins, leukotrienes and essential fatty acids Vol. 64; no. 4-5; pp. 265 - 271
• Main Authors: Cabrini, L, Bergami, R, Maranesi, M, Carloni, A, Marchetti, M, Tolomelli, B
• Format: Journal Article
• Language: English
• Published: Scotland 01.04.2001
• Subjects: Animals; Antioxidants - pharmacology; Diet; Fatty Acids - metabolism; Fatty Acids, Unsaturated - pharmacology; Fish Oils - pharmacology; Glutathione - metabolism; Glutathione Peroxidase - metabolism; Glutathione Reductase - metabolism; Lipid Metabolism; Lipid Peroxidation; Liver - metabolism; Male; Myocardium - metabolism; Plant Oils - pharmacology; Pyridoxine - pharmacology; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Vitamin E - metabolism
• ISSN: 0952-3278

Previous reports have shown that vitamin B(6)deficiency leads to peroxidative stress in rat organs. In this paper, we evaluated the effects on lipid peroxidation of short-term (six weeks) dietary administration of marginal contents of vitamin B(6). A further risk factor of susceptibility to peroxidation was the presence of fish oil with higher contents of n-3 polyunsaturated fatty acid (LCPUFA). The contemporaneous vitamin B(6)deficiency and presence of fish oil caused a C18:2 increase, a C20:4 decrease, and replacement of some n-6 LCPUFA with n-3 LCPUFA, without changes in the unsaturation index. In liver, TBARS production did not show any differences between dietary conditions, whereas the activities of glutathione-dependent enzymes were stimulated. In heart, fish oil increased lipid peroxidation, especially in the vitamin B(6)-deficient group.