Effect of oral supplement of l-glutamine in colonic wall of rats subjected to abdominal irradiation

To evaluate the structural alterations of the irradiated colonic wall in rats, verifying if L-glutamine supplementation is able to prevent them. We used 30 male adult Wistar rats, divided into three groups: I--control, II--irradiated, and III-irradiated with L-glutamine supplementation during the 14...

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Bibliographic Details
Published inActa cirúrgica brasileira Vol. 20 Suppl 1; p. 139
Main Authors Diestel, Cristina Fajardo, Lopes-Paulo, Francisco, Marques, Ruy Garcia, Horsts, Nara Limeira, Caetano, Carlos Eduardo Rodrigues
Format Journal Article
LanguagePortuguese
Published Brazil 2005
Subjects
Abdominal Wall
Administration, Oral
Animals
Colon - drug effects
Colon - pathology
Colon - radiation effects
Glutamine - therapeutic use
Intestinal Mucosa - drug effects
Intestinal Mucosa - pathology
Intestinal Mucosa - radiation effects
Male
Organ Size - drug effects
Organ Size - radiation effects
Radiation Injuries, Experimental - pathology
Radiation Injuries, Experimental - prevention & control
Rats
Rats, Wistar
Statistics, Nonparametric
Time Factors
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Summary:To evaluate the structural alterations of the irradiated colonic wall in rats, verifying if L-glutamine supplementation is able to prevent them. We used 30 male adult Wistar rats, divided into three groups: I--control, II--irradiated, and III-irradiated with L-glutamine supplementation during the 14 days of the study. Control group was maintained in laboratory standard conditions while groups II and three were submitted to abdominal radiation with an only dose of 1000 cGy in the 8th day of experimentation. All the animals were submitted to laparotomy in the 15th day for resection of the colonic segment for stereological analysis. Group II presented total volume of colonic wall significantly smaller than control group without altering the partial volumes of each layer. Compared to groups II and III, group II exhibited maintenance of total volume of colonic wall, nearing control group. Compared to control group, animals of group III exhibited maintenance of epithelial partial volume without altering significantly epithelial surface. It is suggested that L-glutamine supplementation can be of benefit in the irradiated colonic wall in rats.
ISSN:0102-8650