Mycophenolate mofetil and cyclosporine in the treatment of steroid-dependent nephrotic syndrome with frequent relapses

We describe the case of an 8-year-old patient, with steroid-dependent minimal lesion nephrotic syndrome, with frequent relapses despite treatment with cyclosporine. After the switch to mycophenolate mofetil the patient had new relapses, and there was difficulty in controlling the disease. The reintr...

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Published inAnales de pediatría (Barcelona, Spain : 2003) Vol. 69; no. 3; pp. 258 - 262
Main Authors Márquez Peiró, J F, Porta Oltra, B, Marín Serra, J
Format Journal Article
LanguageSpanish
Published Spain 01.09.2008
Subjects
Child
Cyclosporine - therapeutic use
Humans
Immunosuppressive Agents - therapeutic use
Male
Mycophenolic Acid - analogs & derivatives
Mycophenolic Acid - therapeutic use
Nephrotic Syndrome - drug therapy
Recurrence
Steroids
Time Factors
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Summary:We describe the case of an 8-year-old patient, with steroid-dependent minimal lesion nephrotic syndrome, with frequent relapses despite treatment with cyclosporine. After the switch to mycophenolate mofetil the patient had new relapses, and there was difficulty in controlling the disease. The reintroduction of cyclosporine combined with mycophenolate mofetil obtained an optimal response, with a longer relapse-free time. Due to their kinetic variability, the blood levels of both drugs were closely monitored during follow-up.
Bibliography:ObjectType-Case Study-2
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ISSN:1695-4033