Effectiveness of eradication anti-helicobacter therapy in patients with duodenal ulcer in different drug dosage regimens

46 patients having exacerbation of duodenal ulcer in the presence of Helicobacter pylori (HP) were studied for efficacy of HP eradication treatment which comprised omeprazole (40 mg/day), colloid bismuth subcitrate (480 mg/day) and metronidazole (1000 mg/day) for 2 weeks. According to the dosage reg...

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Bibliographic Details
Published inKlinicheskaia meditsina Vol. 81; no. 6; p. 48
Main Authors Orziev, Z M, Nurbaev, F E, Rakhimova, G Sh
Format Journal Article
LanguageRussian
Published Russia (Federation) 2003
Subjects
Adolescent
Adult
Anti-Bacterial Agents - administration & dosage
Anti-Ulcer Agents - administration & dosage
Bismuth - administration & dosage
Drug Administration Schedule
Drug Therapy, Combination
Duodenal Ulcer - complications
Duodenal Ulcer - drug therapy
Duodenal Ulcer - microbiology
Female
Helicobacter Infections - complications
Helicobacter Infections - drug therapy
Helicobacter pylori - drug effects
Humans
Male
Metronidazole - administration & dosage
Omeprazole - administration & dosage
Treatment Outcome
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Summary:46 patients having exacerbation of duodenal ulcer in the presence of Helicobacter pylori (HP) were studied for efficacy of HP eradication treatment which comprised omeprazole (40 mg/day), colloid bismuth subcitrate (480 mg/day) and metronidazole (1000 mg/day) for 2 weeks. According to the dosage regimen the patients were divided into two groups. Patients of group 1 received the drugs in fractions, of group 2--in a single daily doses. The eradication therapy in both dosage regimen was high (73 and 88%, respectively). Thus, it is proved that single daily doses of actibacterial drugs can be also used in clinical practice for conduction of eradication therapy.
ISSN:0023-2149