Reactive oxygen species and vascular hyporeactivity in septic shock. Part II--scavengers and vascular hyporeactivity in septic shock

Reactive oxygen species (ROS) are formed as a result of physiologic cellular metabolism and although they are essential for signalization they also, when produced in excess, contribute to the pathogenesis of many diseases. This paper is an attempt to summarize the role of ROS in the development of s...

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Bibliographic Details
Published inPolski merkuriusz lekarski Vol. 23; no. 136; p. 284
Main Author Gendzwiłł, Anna
Format Journal Article
LanguagePolish
Published Poland 01.10.2007
Subjects
Endothelium, Vascular - metabolism
Free Radical Scavengers - metabolism
Hemodynamics
Humans
Reactive Oxygen Species - metabolism
Shock, Septic - metabolism
Signal Transduction - physiology
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Summary:Reactive oxygen species (ROS) are formed as a result of physiologic cellular metabolism and although they are essential for signalization they also, when produced in excess, contribute to the pathogenesis of many diseases. This paper is an attempt to summarize the role of ROS in the development of septic shock. At the beginning scavengers that counteract the excessive action of ROS are discussed. In the next part, the problem of how the presence of lipopolysaccharide changes the cellular metabolism into production of proinflammatory agents, leading to the patient's death, is discussed.
ISSN:1426-9686