In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci

The in vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys against gram-positive cocci were investigated. Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and Rhodococcus equi. A positive interaction was shown when the lipopeptides w...

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Bibliographic Details
Published inAntimicrobial agents and chemotherapy Vol. 51; no. 1; p. 354
Main Authors Kamysz, Wojciech, Silvestri, Carmela, Cirioni, Oscar, Giacometti, Andrea, Licci, Alberto, Della Vittoria, Agnese, Okroj, Marcin, Scalise, Giorgio
Format Journal Article
LanguageEnglish
Published United States 01.01.2007
Subjects
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Drug Resistance, Multiple, Bacterial
Drug Synergism
Gram-Positive Cocci - classification
Gram-Positive Cocci - drug effects
Hemolysis - drug effects
Humans
Lipoproteins - chemical synthesis
Lipoproteins - chemistry
Lipoproteins - pharmacology
Microbial Sensitivity Tests
Molecular Structure
Peptides - chemical synthesis
Peptides - chemistry
Peptides - pharmacology
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Summary:The in vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys against gram-positive cocci were investigated. Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and Rhodococcus equi. A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin. These results suggest that lipopeptides are promising candidates for antimicrobial therapy for infections caused by gram-positive organisms.
ISSN:0066-4804