Analysis of group B streptococcal gene scaAB encoding the protein involved in adherence and aggregation

The portion of group B streptococcal (GBS) sequence encoding the ABC transport system was cloned and sequenced. The genetic region under study included scaAB gene, which was capable of encoding for putative adherence and aggregation factor, and scaR, which was encoding for putative represser. After...

Full description

Saved in:
Bibliographic Details
Published inMolekulârnaâ genetika, mikrobiologiâ i virusologiâ no. 3; p. 9
Main Authors Vorob'eva, E I, Vorob'eva, O V, Suvorova, A N
Format Journal Article
LanguageRussian
Published Russia (Federation) 2005
Subjects
Adhesins, Bacterial - genetics
Bacterial Adhesion
Bacterial Proteins - genetics
Cloning, Molecular
Epithelium - microbiology
Female
Genes, Bacterial
Humans
Mutagenesis, Insertional
Sequence Analysis, DNA
Streptococcus agalactiae - genetics
Streptococcus agalactiae - pathogenicity
Vagina - cytology
Virulence - genetics
Online AccessGet more information

Cover

More Information
Summary:The portion of group B streptococcal (GBS) sequence encoding the ABC transport system was cloned and sequenced. The genetic region under study included scaAB gene, which was capable of encoding for putative adherence and aggregation factor, and scaR, which was encoding for putative represser. After the insertional inactivation of scaAB gene on the GBS chromosome streptococci increased the tendency for aggregation. The level of GBS adherence to vaginal epithelium was also different after scaAB inactivation. GBS sea operon was compared to similar ABC encoding bacterial operons.
ISSN:0208-0613