Comparative characteristics of A1-receptor agonists as neuroprotective agents

Comparative characteristics of a series of selective A1 agonists influencing the complex global cerebral ischemia (CGCI) are presented and the optimum conditions for realization of the neuroprotective effect are selected. The degree of the neuroprotective action blocking by theophylline and 8-cyclop...

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Bibliographic Details
Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 64; no. 5; p. 19
Main Authors Kulinskiĭ, V I, Minakina, L N, Usov, L A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.2001
Subjects
Adenosine - analogs & derivatives
Adenosine - pharmacology
Adenosine - therapeutic use
Animals
Brain Ischemia - prevention & control
Hypothermia - chemically induced
Mice
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Purinergic P1 Receptor Agonists
Purinergic P1 Receptor Antagonists
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Summary:Comparative characteristics of a series of selective A1 agonists influencing the complex global cerebral ischemia (CGCI) are presented and the optimum conditions for realization of the neuroprotective effect are selected. The degree of the neuroprotective action blocking by theophylline and 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) decreases in the following order: CPA CHA ADAC. The A1-receptor agonists exhibit both direct action upon brain (maximum for ADAC) and a peripheral mechanism (especially pronounced for CPA). There is a close correlation between the neuroprotective activity of the A1-receptor agonists and their hypothermal effect. It is suggested that the hypothermal action plays an important part in the neuroprotective activity of the A1-receptor agonists.
ISSN:0869-2092