Synthesis and quarternization of 6-(substitutedamino)-purines with antitumor activity screening

Reaction of 6-chloro-9-benzyl-8-(methylthio)purine 3 with primary amines afforded, the corresponding 6-(substitutedamino)purines 4a-g. The latter products when methylated with methyl iodide yielded smoothly N3-methyl purinium iodide salts 5a-f rather than the probable N1- and N7-derivatives. 9-Benzy...

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Bibliographic Details
Published inArchives of pharmacal research Vol. 17; no. 2; p. 60
Main Authors el-Bayouki, K A, Basyouni, W M, el-Din, S M, Habeeb, A G
Format Journal Article
LanguageEnglish
Published Korea (South) 01.04.1994
Subjects
Animals
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
Cell Survival - drug effects
Drug Screening Assays, Antitumor
Purines - chemical synthesis
Purines - pharmacology
Tumor Cells, Cultured
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Summary:Reaction of 6-chloro-9-benzyl-8-(methylthio)purine 3 with primary amines afforded, the corresponding 6-(substitutedamino)purines 4a-g. The latter products when methylated with methyl iodide yielded smoothly N3-methyl purinium iodide salts 5a-f rather than the probable N1- and N7-derivatives. 9-Benzyl-3-methyl-6-(methylimino)-8-(methylthio)purine 8 was obtained upon treating the purinium iodide 5a with alkali. Most of the synthesized compounds were screened for their antitumor activity.
ISSN:0253-6269