The diagnostic value of the detection of hepatic fibrosis serum markers in chronic viral hepatitis

The diagnostic significance of serum markers of fibrosis was investigated in 92 patients with chronic viral hepatitis (CVH) by studying the collagenolythic activity of blood, proteasic inhibitor activity, collagen metabolism products (oxyproline fraction), and fibronectin. At the same time, the pati...

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Bibliographic Details
Published inKlinicheskaia meditsina Vol. 85; no. 9; p. 61
Main Authors Beloborodova, E I, Abdrashitov, R F, Beloborodova, E V, Burkovskaia, V A, Akbashaeva, O E, Purlik, L I, Rachkovskiĭ, M I, Lambrova, E G, Alekseeva, A S, Petrova, L A, Ostanko, V L, Sinicheva, Iu I, Kalacheva, T P
Format Journal Article
LanguageRussian
Published Russia (Federation) 2007
Subjects
Adolescent
Adult
Biomarkers - blood
Biopsy
Chronic Disease
Collagenases - blood
Disease Progression
Female
Hepatitis, Viral, Human - blood
Hepatitis, Viral, Human - diagnosis
Humans
Male
Middle Aged
Prognosis
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Summary:The diagnostic significance of serum markers of fibrosis was investigated in 92 patients with chronic viral hepatitis (CVH) by studying the collagenolythic activity of blood, proteasic inhibitor activity, collagen metabolism products (oxyproline fraction), and fibronectin. At the same time, the patients underwent puncture biopsy of the liver, which made it possible to determine the degree of process activity and the stage of its chronization. As the degree of fibrosis grew, the collagenase serum activity increased significantly, while the alpha1-proteinase inhibitor activity fell, the content of oxyproline (its fractions) increased, and the fibronectin level decreased. Hence, the measurement of the noted parameters allows for noninvasive diagnostics of CVH stages.
ISSN:0023-2149