Polyamines antagonizing angiotensin II contractile effects in isolated rat aorta

Our study showed that the administration in pre-treatment of some polyamines (especially spermine and spermidine and almost null agmatine, putrescine and cadaverine) reduced the contractile effects of angiotensin II (Ang II) in isolated rat aorta. These effects might not be associated to the interfe...

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Bibliographic Details
Published inRevista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi Vol. 107; no. 2; p. 361
Main Authors Costuleanu, Natalia, Foia, Liliana, Slătineanu, Simona Mihaela, Indrei, L L, Costuleanu, M, Petrescu, Gh
Format Journal Article
LanguageRomanian
Published Romania 01.04.2003
Subjects
Algorithms
Analysis of Variance
Angiotensin II - antagonists & inhibitors
Angiotensin II - pharmacology
Animals
Aorta - drug effects
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiology
Muscle Contraction - drug effects
Muscle Contraction - physiology
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - physiology
Polyamines - pharmacology
Rats
Rats, Wistar
Spermidine - pharmacology
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Summary:Our study showed that the administration in pre-treatment of some polyamines (especially spermine and spermidine and almost null agmatine, putrescine and cadaverine) reduced the contractile effects of angiotensin II (Ang II) in isolated rat aorta. These effects might not be associated to the interference of clathrin coated vesicles (coated pits) formation or caveolae interaction (and thus to Ang II internalization through AT1 receptors). In contrast, these effects seem to be due to the interaction with voltage-gated membrane Ca2+ channels. Therefore, the alteration of transmembrane Ca2+ fluxes does not exclude the involvement of internalization process through coated pits or caveolae, since the endocytosis mediated by these phenomena essentially needs Ca2+. In addition, the inhibitory effects are dependent on the number of positive charges of the polyamine molecules.
ISSN:0048-7848