Apolipoprotein E epsilon4 allele and neurobehavioral status after on-pump coronary artery bypass grafting

• Published in: Journal of cardiac surgery Vol. 20; no. 5; pp. 501 - 505
• Main Authors: Askar, Fatma Zekiye, Cetin, Hasan Yurday, Kumral, Emre, Cetin, Ozgul, Acarer, Ahmet, Kosova, Buket, Yagdi, Tahir
• Format: Journal Article
• Language: English
• Published: United States 01.09.2005
• Subjects: Alleles; Apolipoprotein E4; Apolipoproteins E - blood; Cognition; Cognition Disorders - diagnosis; Cognition Disorders - etiology; Coronary Artery Bypass - adverse effects; Female; Genotype; Humans; Male; Middle Aged; Neuropsychological Tests
• ISSN: 0886-0440

Abstract Background and Aim: The presence of apolipoprotein E epsilon4 allele is being considered as a risk factor for cognitive decline after cardiac surgery. We sought the effect of apolipoprotein E epsilon4 allele on neurobehavioral status after on-pump coronary artery bypass grafting. Prior to the operation, neurologic examination and neurobehavioral cognitive status test (COGNISTAT) were performed. Both procedures were repeated on the day of discharge and 3 months after surgery. Apolipoprotein E epsilon4 allele positive and apolipoprotein E epsilon4 allele negative patients' performance on COGNISTAT were compared. There was no statistically significant demographic and operative data difference between two groups. No neurological impairment was observed on examinations. There was no statistically significant neurocognitive decline difference between two groups' postoperative performances. It seems that apolipoprotein E epsilon4 allele may not affect neurobehavioral status in the intermediate period after on-pump coronary artery bypass grafting.