The central mechanisms regulating the blood circulation in hyperuricemia

In experiments conducted on male Wistar rats for elucidation the role of central mechanisms in development alterations of heart electric stability was studied activity of 5(1)-nucleotidase and adenosine desaminase in sensomotor cortex, hypothalamus and hippocamp. Were shown that changes of heart fun...

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Published inFiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Vol. 45; no. 1-2; pp. 87 - 96
Main Authors Barynov, E F, Syniachenko, O V, Hryn', V K, Bondarenko, N M, Barynova, M E
Format Journal Article
LanguageUkrainian
Published Ukraine 1999
Subjects
Adenosine - metabolism
Animals
Blood Circulation - physiology
Brain - physiopathology
Brain Chemistry - physiology
Cyclic AMP - metabolism
Cyclic GMP - metabolism
Disease Models, Animal
Electrophysiology
Gout - metabolism
Gout - physiopathology
Heart - physiopathology
Male
Rats
Time Factors
Uric Acid - blood
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Summary:In experiments conducted on male Wistar rats for elucidation the role of central mechanisms in development alterations of heart electric stability was studied activity of 5(1)-nucleotidase and adenosine desaminase in sensomotor cortex, hypothalamus and hippocamp. Were shown that changes of heart function were in case increased adenosine content in neurons of sensomotor cortex, hypothalamus and hippocamp. Introduction to animals with hyperuricemia DOCA, with activate 5(1)-nucleotidase and adenosine desaminase, was accompanied by changes of cAMP and cGMP content in neurons. Developing alterations of heart electric stability suggest the responsibility of injury adenosine metabolism in different brain structures of animals with hyperuricemia in alterations of central regulatory mechanisms of systemic blood flow.
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ISSN:2522-9028