Significance of mitochondria in the heart muscle

Besides their traditional role as the energy factory of the cell, mitochondria play an important role in other aspects of cardiac cell functioning under physiological and pathological conditions. They are involved in the regulation of calcium homeostasis, production of reactive oxygen species as wel...

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Bibliographic Details
Published inČasopis lékařů českých Vol. 143; no. 12; p. 809
Main Authors Skárka, L, Ost'ádal, B
Format Journal Article
LanguageCzech
Published Czech Republic 2004
Subjects
Animals
Apoptosis
Calcium - metabolism
Energy Metabolism
Free Radicals - metabolism
Heart - physiology
Humans
Mitochondria, Heart - metabolism
Mitochondria, Heart - physiology
Myocardial Ischemia - metabolism
Myocardium - metabolism
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Summary:Besides their traditional role as the energy factory of the cell, mitochondria play an important role in other aspects of cardiac cell functioning under physiological and pathological conditions. They are involved in the regulation of calcium homeostasis, production of reactive oxygen species as well as in the process of cardiac cell death. Recently, the interest in their participation in ischemia-reperfusion injury and potential role in cardioprotective mechanisms, with particular attention to developmental aspects has markedly increased.
ISSN:0008-7335